quinta-feira, 25 de junho de 2009


Tensegrity I. Cell structure and hierarchical systems biology

By Donald E. Ingber:

( "...The fact that the germ-cell develops into a very complex structure is no absolute proof that the cell itself is structurally a very complicated mechanism: nor yet does it prove, though this is somewhat less obvious, that the forces at work or latent within it are especially numerous and complex..." - D'Arcy W. Thompson (Growth and Form, 1917))

"In 1993, a commentary in the Journal of cell science described how a simple mechanical model of cell structure based on tensegrity architecture can help to explain how cell shape, movement and cytoskeletal mechanics are controlled, as well as how cells sense and respond to mechanical forces (Journal of Cell Science. 104, 613-627).

The cellular tensegrity model can now be revisited and placed in context of new advances in our understanding of cell structure, biological networks and mechanoregulation that have been made over the past decade.
Recent work provides strong evidence to support the use of tensegrity by cells, and mathematical formulations of the model predict many aspects of cell behavior. In addition, development of the tensegrity theory and its translation into mathematical terms are beginning to allow us to define the relationship between mechanics and biochemistry at the molecular level and to attack the larger problem of biological complexity.
Part I of the two-part article covers the evidence for cellular tensegrity at the molecular level and describes how this building system may provide a structural basis for the hierarchical organization of living systems — from molecule to organism.
Part II focuses on how these structural networks influence information processing networks."

Abstract from Journal of Cell Science, article by Donald E. Ingber

model-image of tensegrity structures: unknown author

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